June 2010 – It was approved to establish a national innovative science and technology park by the Ministry of Science and Technology.

September 2010 – Hefei National High-tech Industry Development Zone became the first national eco-industry demonstration zone in Anhui province.

December 2010 – Hefei National High-tech Industry Development Zone became one of the first 13 national demonstration zones for centralized application of photovoltaic power generation.

June 2011 – It jumped to 12th place in the comprehensive evaluation of national high-tech zones.

December 2011 –Hefei National High-tech Industry Development Zone reached its target of 100 billion yuan ($14.57 billion) a year ahead of schedule. Obtaining a total industrial output value of 101.5 billion yuan, it became the first high-tech industry development zone in Anhui province with an output value exceeding 100 billion yuan.

May 2012 – It became one of the first 16 national demonstration bases for cultural and scientific integration.

October 2012 – Hefei and the University of Science and Technology of China signed a comprehensive strategic cooperation agreement in Hefei National High-tech Industry Development Zone, and the Institute of Advanced Technology of the University of Science and Technology of China was inaugurated.

January 2013 – The Science and Technology Innovation Public Service Center of Hefei-Wuhu-Bengbu Independent Innovation Experimental Zone was officially opened in Hefei National High-tech Industry Development Zone.

May 2013 – The opening ceremony of Chaohu Industrial Park was held in Hefei National High-tech Industry Development Zone.

August 2013 – The list of the second batch of smart city pilots was issued by the Ministry of Housing and Urban-Rural Development and Hefei National High-tech Industry Development Zone was selected as the only smart city (district or county) pilot in Hefei.

April 2014 – The Management Committee of Hefei National High-tech Industry Development Zone signed a strategic cooperation agreement with Shanghai Stock Exchange.

June 2014 – The launching ceremony of CAS (Hefei) Institute of Technology Innovation was held in Hefei National High-tech Industry Development Zone.

September 2014 – Hefei National High-tech Industry Development Zone was awarded the title of "National Ecological Industrial Park" by the Ministry of Environmental Protection (currently the Ministry of Ecology and Environment), the Ministry of Science and Technology and the Ministry of Commerce, becoming the first national ecological industrial park in Anhui province.