For many years, the usual way to get to Macau was to fly into Hong Kong and take the ferry across to Macau. Today, Macau is becoming a low-cost airline hub, so one might fly to Macau to reach Hong Kong.
Most visitors do not need visas, with 30-90 day permits issued for free on entry. See the Macau Tourism Office web-site for the details. For those requiring a visa, they have to be obtained from a Chinese embassy or consulate, and applied for separately from the mainland Chinese one.
Like Hong Kong, Macau has a separate immigration regime from mainland China and anyone going to Macau from the mainland is deemed to be leaving China. If you want to re-enter China from Macau, you'll have to apply for another Chinese visa unless your earlier one is a multiple entry visa.
By plane
Macau International Airport is off the shore of Taipa Island. It has basic facilities and a couple of aerobridges, but it is possible that you will park on the tarmac and take a bus to the terminal.
Macau's home carriers are Air Macau and low-cost competitor Viva Macau. While nowhere nearly as well served as Hong Kong, the airport is popular among low-cost airlines thanks to its low landing fees. Air Asia flies to Macau from all over South-East Asia, while Tiger and Jetstar serve Singapore, Philippine and Cebu serve Manila, Bangkok Airways flies to Bangkok.
Bus AP1 plies a route between the airport and the Barrier Gate. Its route passes through several points on Taipa Island, and it stops at the ferry terminal on the peninsula on the way. It costs MOP3.30 per passenger, and MOP3.00 per bag. It has limited provision for baggage, and can be very crowded (you may not even get the first bus to arrive). Change at the ferry terminal for other destinations, the frequent number 3 bus runs from the ferry terminal and passes the Lisboa, Landmark Hotel, and Holiday Inn, or catch one of the hotel/casino shuttles which go the ferry terminal. The buses do not give change, but there is a currency exchange just inside the terminal that will change foreign currency into low denomination MOP.
Alternatively, take a metered taxi straight to your destination, but there's a MOP 5 airport surcharge plus MOP 2 for the bridge and MOP 3 per bag. Fares to the city center are around MOP 40-50, the trip taking 15-20 minutes.
If you are bound for Zhuhai, there is a special bus you can take from Macau airport direct to the border, without going through Macau Customs or Immigration. See the Zhuhai article for details.
Connections to mainland China are astonishingly limited, with service only to Shanghai and Beijing (as of 2009). It is usually cheaper to fly to Zhuhai and cross the border by land as flights between Macau and the mainland are considered to be international flights.
See also Discount airlines in Asia.
By helicopter
The Sky Shuttle helicopter service operates every 15-30 minutes between Macau's Terminal Maritimo and the Hong Kong-Macau Ferry Pier in Hong Kong, as well as five times a day to/from Shenzhen airport. The trip takes just 16 minutes, but weekday/weekend tickets cost a whopping $2200/2400 one-way.
By boat
This is still the main way in which most visitors get to Macau. The main ferry terminal in Macau is the Macau Ferry Terminal (Terminal Maritimo) at the Outer Harbour (Porto Exterior). This is a busy terminal handling most of the sea traffic between Macau and Hong Kong as well as the Chinese ports of Shekou and Shenzhen International Airport. Getting there/away: Buses 1A, 3, 3A, 10, 10A, 10B, 12, 28A, 28B, 28BX, 32 and AP1 run from the ferry terminal. The bus stop is on the main road to the right as you walk out of the building. Pick up a free bus schedule in the tourist information centre in the building. If you are heading straight to a casino or hotel, most of these establishments provide free shuttle buses. They gather to the left of the terminal building; step out of the arrival-level of the building and turn left.
There is a lesser known ferry terminal in Macau, located at Pier No. 11 at the Inner Harbour. This is a new ferry terminal building after its former Pier 14 site was given to developers by the Macau Government. It is very near to the Macau city centre and can be easily reached on foot. This terminal mostly services boats to Shenzhen, Jiangmen and Wanzai across the Inner Harbour in Zhuhai, China.
A third temporary ferry service serves Taipa, Cotai and Coloane connecting to Hong Kong. The Taipa Temporary Ferry Terminal is adjacent the Ponte da Amizade Friendship Bridge on Estrada de Pac On, and is served by bus AP1 from the city to the airport, but not the other way around (unless you go around the entire loop). There is also a free shuttle bus to the Venetian. A larger permanent ferry terminal is being constructed between the temporary terminal and the Macau International Airport, scheduled for completion in 2010.
(Source: Wikitravel)