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Scientists find way to 'disarm' HIV virus
艾滋病病毒可被“缴械”

Activists distribute red ribbons and light up candles as they commemorate victims of the Human Immunodeficiency Virus, or HIV, during a flashmob in St.Petersburg May 16, 2010. [Reuters]

Activists distribute red ribbons and light up candles as they commemorate victims of the Human Immunodeficiency Virus, or HIV, during a flashmob in St.Petersburg May 16, 2010. [Reuters]
Scientists have found a way to prevent HIV from damaging the immune system and say the discovery may offer new clues to developing a vaccine against AIDS, Reuters reported. 据路透社报道,科学家已找到一种办法防止艾滋病病毒破坏免疫系统。他们表示,这一发现可为开发艾滋病疫苗提供新线索。 
HIV Researchers from the United States and Europe have found the virus is unable to damage the immune system if cholesterol is removed from the virus's membrane. 美国和欧洲的研究人员发现,如果从病毒细胞膜上移除胆固醇,病毒便无法破坏免疫系统。
"It's like an army that has lost its weapons but still has flags, so another army can recognize it and attack it," said Adriano Boasso of Imperial College London, who led the study. 来自伦敦帝国理工学院的研究带头人阿德里亚诺•博阿索说:“这就像一支部队,他们丢了武器,却还有旌旗,所以另一支部队能认出他们并展开攻击。”
Usually when a person becomes infected with HIV, the body's innate immune response puts up an immediate defense. But some researchers believe HIV causes the innate immune system to overreact. This weakens the immune system's next line of defense, known as the adaptive immune response. 通常情况下,当人感染艾滋病病毒后,先天性免疫反应便立即实施防卫。但一些研究人员认为,艾滋病病毒可使先天免疫系统反应过激。这就削弱了免疫系统的下一道称为适应性免疫反应的防线。
In their study, Boasso's team removed cholesterol from the membrane around the virus and found that this stopped HIV from triggering the innate immune response. This in turn led to a stronger adaptive response, orchestrated by the type of white blood cells known as T cells. 而在这项研究里,博阿索的团队从病毒周围细胞膜上移除胆固醇,发现这可阻止艾滋病病毒激发先天性免疫反应。接下来在一种称为T细胞的免疫细胞的配合下,可引起更为强烈的适应性反应。

The findings have given researchers new hope that they will be able to develop vaccines that can disable the virus.

 

(China.org.cn September 21, 2011)

这些发现使得研究者有望开发出能够抑制病毒的疫苗。

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