The three representatives from the Premier League - Chelsea, Arsenal, and Manchester United - were all dealt away ties first due to their ranking in the group stages and Carlo Ancelotti's Blues take on Jose Mourinho's Internazionale side.
It will be a particularly intriguing fixture due to the high regard Mourinho is still held in at Stamford Bridge, and the charismatic Portuguese also harbours a testy relationship with Ancelotti.
It will be a David Beckham homecoming as the side he will be on loan, AC Milan, will play their second leg at Manchester United's Old Trafford ground; a stage where he dazzled with his extraordinary ability from dead ball situations.
Arsenal, meanwhile, take on FC Porto - a side they have had the better of judging by contemporary results. The Dragaos defeated the Gunners at the Estadio do Dragao in 2008 by a 2-0 scoreline, but slipped to a 4-0 loss at the Emirates.
Full Champions League Draw:
Stuggart VS Barcelona
Olympiakos VS Girondins de Bordeaux
Internazionale VS Chelsea
Bayern Munich VS Fiorentina
CSKA Moscow VS Sevilla
Olympique Lyonnais VS Real Madrid
FC Porto VS Arsenal
AC Milan VS Manchester United